Anisomeles malabarica (Linn.) R.Br.is a traditional medicinal plant of Lamiaceae family, distributed throughout India. The methanolic extracts of Anisomeles malabarica (Linn.) R.Br. were tested for Antimicrobial efficacy against the fungal organisms. The methanolic extract of Anisomeles malabarica (Linn.) R.Br. were exhibited maximum anti fungal activity. Hence it can be concluded that the methanolic extract of Anisomeles malabarica (Linn.) R.Br. possess a significant Antimicrobial activity. This also stands as a scientific support for the usage of this plant for fungi toxic activities, inhibiting the growth of Aspergillus flavus and Aspergillus parasiticus and thus could be considered as an alternative inhibitor of the survival of this fungus in foodstuffs, in addition to offer some protective effect to the production of aflatoxins