Diabetes mellitus causes damage and dysfunctions for many organs and systems, lipid abnormalities is one of the diabetes dysfunctions, it commonly occurs in type2 DM, so analysis of serum lipids has become an important health concern. The study aimed to measure HbA1C, fasting blood glucose and lipid profile in type 2 Diabetes mellitus. A descriptive cross sectional hospital based design the study was conducted in Khartoum state among Sudanese diabetic patients involving a total of 50 subjects the age round between (40-70) years of both sexes from January 2015 to May 2015. The sera of 50 Type 2 diabetic patients was analyzed for fasting blood sugar (FBS), HbA1 c and lipid profile consisting of total cholesterol (TC), triglycerides (TG), High-density Lipoprotein (HDL) cholesterol and LDL cholesterol. The subjects were divided based on their glycemic index into two groups; Group 1-controlled diabetic subjects (HbA1c < 7 and group-2, uncontrolled (HbA1c >9%). The mean age ±SD was 55.2± 10 years. The mean value of HbA1c , Fasting blood sugar (FBS), total cholesterol, Triglycerides, LDL-Chol, HDL-Chol were 8.6± 2.7, 153.3± 56.3, 156.0± 40.2, 111.4± 60.8, 96.2± 36.0 and 45.6± 19.6 respectively. The lipid profile parameters (TC, TG, LDL) were significantly elevated in un-controlled subjects and moderate subjects as compared with controlled (P>0.05). The FBS concentration was significantly higher in un-controlled subjects as compared with controlled subjects (P<0.05). While the HDL was statistically not significantly elevated in uncontrolled compared to control group. The mean value of FBS was slightly higher in females in comparison to male patients but the differences were not significant. Among the circulating lipids, TC and LDL-C, TAG were not significantly higher (P>0.05) in females patients. Although the mean level of HDL-C not significantly slightly higher in males than females, these differences were statistically non-significant. The highly direct significant correlation between HbA1c and FBS and HbA1c and TC was observed. The study concluded that; an elevation of total serum cholesterol, Triglyceride, LDLC and low HDL-C were observed in type 2 diabetics un-controlled subjects compared to controlled subjects. Diabetic patients should be educated about regular monitoring of lipid profiles and if found to be abnormal, should control blood sugar and lipids very effectively