Piliostigma reticulatum is a medicinal plant used in Côte d’Ivoire in the traditional treatment of digestive disorders such as diarrhoea. To assess its safety, the hydro-ethanolic and dichloromethanic extracts of the stem bark were administered orally for 28 days to six groups of rats at doses of 250, 500 and 1000 mg / kg body weight for the hydro-ethanolic extract and 125, 250 and 500 mg / kg body weight for the dichloromethanic extract. The negative control group received distilled water and the positive control group received a single intraperitoneal dose of 400 mg / kg body weight of urethane. The daily measurements of the quantities of food and water consumed and the weekly weighing of the rats were used to estimate the effect of the extracts on anthropometric parameters. The microscopic examinations of the bone marrow were used to assess the genotoxicity of the extracts. These extracts had no major effect on the food intake and the weight gain of the rats. Only the consumption of water has increased considerably in the last week of the experiment at all the doses for the dichloromethanic extract and 1000 mg / kg body weight for the hydro-ethanolic extract. As regards the genotoxicity, the micronuclei induction effects of these extracts are almost negligible