ISSN

2277 - 3282

e ISSN

2277 - 3290

Publisher

Journal of Science

IN VITRO EVALUATION OF EFFECT OF CASSYTHA FILIFORMIS L. EXTRACTS ON BRAIN NEUROTRANSMITTERS IN ALBINO RATS
Author / Afflication
P. Govardhan

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Science, Bollikunta, Warangal, Andhra Pradesh, India
Jagdeesh Bandari

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Science, Bollikunta, Warangal, Andhra Pradesh, India
Suresh Bandari

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Science, Bollikunta, Warangal, Andhra Pradesh, India
K. Praveen Kumar

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Science, Bollikunta, Warangal, Andhra Pradesh, India
Keywords
Antiepileptic activit ,Traditional Medicine ,Cassytha filiformis L ,biogenic amines ,GABA ,
Abstract

The stem of Cassytha filiformis L. is used traditional Indian medicine to treat epilepsy.Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. The purpose of the present study is to investigate the effect of ethanolic (95%) extract of Cassytha filiformis L. (EECF) on biogenic amines concentrations in rat brain after induction of seizures by MES and PTZ. Our aim of study was relationship between seizure activities and altered the monoamines such as noradrenaline (NA), dopamine (DA), serotonin (5-HT) and Gamma amino butyric acid (GABA) in forebrain of rats in MES and PTZ seizure models. In MES model, EECF (200 & 400 mg/kg) showed significantly restored the decreased levels of brain monoamines such as NA, DA, 5-HT and GABA. Similarly in PTZ model, EECF showed significantly increased the monoamines in forebrain of rats. Thus, this study suggests that ethanol extract of Cassytha filiformis L. increased the monoamines on rat brain, which may be decreased the susceptibility to MES and PTZ induced seizure in rats

Volume / Issue / Year

1 , 1 , 2011

Starting Page No / Endling Page No

21 - 25