ISSN

2277 - 3282

e ISSN

2277 - 3290

Publisher

Journal of Science

STUDY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY IN NEWBORN IN A TERTIARY CARE CENTRE IN ASSAM, INDIA
Author / Afflication
Ghanashyam Thakuria

Demonstrator, Department of Pathology, Gauhati Medical College & Hospital, Assam- 781032, India.
Debashish Datta

Professor, Department of Pathology, Silchar Medical College & Hospital, Assam- 788014, India.
Amit Muchahary

Demonstrator, Department of Pathology, Gauhati Medical College & Hospital, Assam- 781032, India.
Amit Sinha

Demonstrator, Department of Pathology, Silchar Medical College & Hospital, Assam- 788014, India.
Bidyut Sarma

Demonstrator, Department of Pathology, Silchar Medical College & Hospital, Assam- 788014, India.
Keywords
Glucose 6 phosphate Dehydrogenase ,Neonatal Hyperbilirubinemia ,Hemolysis ,
Abstract

Deficiency of Glucose-6-phosphate dehydrogenase (G6PD) is the most common metabolic disorder of red blood cells leading to hemolytic anemia and neonatal hyperbilirubinemia (NNH). With almost 24 million children born annually in India, it is estimated that atleast 390,000 children suffering from this disorder are born in the country every year. This study was performed to screen the newborn for G6PD deficiency and its incidence and relationship with neonatal hyperbilirubinemia. This study was carried out in the Department of Pathology, Silchar Medical College & Hospital, Silchar in 998 newborn of both sexes from June 2013 to May 2014. Out of 998 newborn, 16 (1.6%) cases were found to have deficiency of G6PD enzyme which included 15 (2.8%) males and 1 (0.2%) female. All 16 (11.5%) cases with G6PD deficiency presented with NNH. Screening for G6PD deficiency should be done in every newborn with jaundice as early diagnosis can reduce the number of complication and prevents future acute haemolytic attacks.

Volume / Issue / Year

7 , 6 , 2017

Starting Page No / Endling Page No

255 - 260