Amit Sinha

Debashish Datta

S. A. Shaikh

Bidyut Sarma

Ghanashyam Thakuria

Amit Kumar Mushahary
Prostate specific Antigen , Fine Needle Aspiration Cytology, Direct Rectal Examination. ,

To correlate FNAC findings of Prostate with blood PSA level in a tertiary care centre, Silchar Medical College and Hospital, Assam (India) for a period of one year. ( June 2013 to May 2014). Men aged 40 years and older with prostatomegaly were studied and Blood PSA level and FNAC findings were compared. 75 patients with a mean age of 63.73 years (range 42-90 yrs) participated in this study. Blood PSA level of 4 ng/ml was taken as cut off. Out of 75 cases ,38 cases showed PSA level less than 4 ng/ml and 37 cases showed PSA level more than 4ng/ml. Out of 38 cases with PSA less than 4ng/ml, one case found to be malignant and 37 case with PSA >4ng/ml ,16 cases were found to be actually malignant on FNAC. Calculating the sensitivity, specificity, and positive predictive value of serum PSA it was found to be 94.11%, 63.79%, and 43.24% respectively. Out of 75 cases, only 49 cases were available for comparasion with histopathology. All the 11 cases diagnosed by FNAC as malignant were found to be malignant and out of 38 benign cases diagnosed by FNAC, 1 case was found to be malignant on histopathology. Calculating sensitivity, specificity, positive predictive value and accuracy of FNAC in diagnosing prostate cancer, it was found to be 91.67%, 100%, 100% and 97.96 % respectively. Taking into consideration the high False positivity of blood PSA and the limited predictive value, and Transrectal Fine needle aspiration cytology being safe, fast, and easy outpatient procedure with high sensitivity and specificity, if it combined with blood PSA estimation it will become an important cost effective OPD procedure for early prostate cancer detection.

7 , 11 , 2017