Department of Dravyaguna, MD Scholar, S.V. Ayurvedic College, Tirupati, Andhra Pradesh, India.

Department of Dravyaguna, MD Scholar, S.V. Ayurvedic College, Tirupati, Andhra Pradesh, India.
Antidiarrhoeal activity ,Ficus glomerata ,traditional medicine ,castor oil- induced diarrhoea ,enteropooling method ,

The present study was to scientifically evaluate anti-diarrhoeal effects of methanolic extract of leaves of Ficus glomerata L. was studied against castor oil-induced-diarrhoea model in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Standard drug atropine (3mg/kg, i.p) showed significant reductions in fecal output and frequency of droppings whereas Ficus glomerata at the doses of 100 and 200 mg/kg i.p significantly retarded the castor-oil induced enteropooling and intestinal transit. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. Ficus glomerata at the doses of 100 and 200 mg/kg significantly inhibited (P<0.001) weight and volume of intestinal content. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent

1 , 1 , 2011