Jahnabi Saharia

Rang Nath Chaubey

Sumita Dutta Gupta

Mili Das

Jyoti Chaubey

Sampriti Baruah
Estrogen receptor, Progesterone receptor, Endometrium, Dysfunctional uterine bleeding. ,

Abnormal uterine bleeding is one of the commonest gynecological problems in clinical practice. It most commonly arises from hormonal disturbances which produce dysfunctional uterine bleeding (DUB). DUB is defined as abnormal bleeding from the uterus, unassociated with tumour, inflammation and pregnancy. To study the immunohistochemical expression of Estrogen and Progesterone receptors in endometrium in DUB patients.50 patients of DUB, in age group 15-49 years were included in study group, from whom, endometrial dilatation and curettage samples were collected. 15 control samples were taken from hysterectomy specimen of women presenting with utero-vaginal prolapse, having normal menstrual history. Histopathological study and immunohistochemical study for estrogen receptor (ER) and progesterone receptor (PR) were done in endometrium of all the above cases and controls.The ER and PR expressions in both glands and stroma of endometrium were significantly higher in DUB group than control group (p-value < 0.001). The ER and PR expressions in both glands and stroma of endometrium were significantly higher in DUB proliferative, DUB Non-atypical hyperplasia and DUB Disordered proliferative than Control proliferative endometrium (p-value < 0.001). The PR expression in stroma and PR total score of endometrium were significantly higher in DUB secretory than Control secretory (p-value < 0.05). The ER and PR expressions in both glands and stroma of endometrium were significantly higher in DUB Non-atypical hyperplasia than DUB Atypical hyperplasia (p-value < 0.05).ER and PR expressions of endometrium were significantly higher in DUB cases than controls. So we can conclude that hormonal therapy will be effective in management of DUB. Steroid hormone receptor analysis play an important role to predict the response to hormonal therapy. Thus Immunohistochemical evaluation of ER and PR expressions in endometrium in DUB will help to provide evidence based hormonal treatment and prevent unnecessary surgeries.

8 , 2 , 2018