Vaageswari College of Pharmacy, Karimnager, Andhra Pradesh, India

VaagdeviCollege of Pharmacy, Medicinal Chemistry Research Division, Hanamkonda, Warangal, Andhra Pradesh, India
Bleeding time ,Clotting time , Euphorbia nivulia ,Haemostasis ,rats ,

The study investigated the haemostatic effect of aqueous extract of Euphorbia nivulia Buch.-Ham. in rats using tail bleeding time and blood clotting time. Rats were divided into four groups of five rats (n=5) animals. Group I served as normal control, Group II received 200mg/kg b w, group III were given 400mg/kg b w while Group IV were administered with 800mg/kg b w of the extract intra-peritoneally for a period of ten days respectively. The findings of this study revealed a significantly decreased (P<0.05) bleeding time and clotting time at all doses 200, 400 and 800md/kg b w after 3rd day, with a non-significantly decreased (p>0.05) time observed after 6th and 10th day of administration plant extract respectively. In conclusion, this justifies the traditional use of Euphorbia nivulia in stoppage of blood bleeding

4 , 5 , 2014