Postoperative complications may either be general or specific to the type of surgery undertaken and should be managed with the patient's history in mind. Common general postoperative complications include fever, atelectasis, wound infection, embolism and deep vein thrombosis (DVT). This study aimed to assess D-dimer level for Pre and Post-Surgical Operation Patients.Thirty patients were enrolled with two types of surgery; Elective surgery and emergency surgery. Estimation of Ddimer quantitative level was performed by quantitative immunoassay using I-CHROMATM kit and reader. D -dimer level was performed preoperative as baseline and postoperative at day1 and day 3. The results were correlated with age, sex, history of surgery and operation time. The highest level D-dimer was obtained at Day 3. Patients over 40 years age operated by elective surgery for more than 2 hours operation time were associated with increased level of D-dimer. D-dimer test should be performed before surgery as baseline and post-operative to exclude the risk of DVT. Surgeons should consider a special protocol with the older age patients requested for surgery. Type of surgery, sex, and operation time had an association with risk factors of DVT. On the other hand, patients with clinically known by DVT will also find useful treatment management after surgery. We advise to manage the anticoagulant dose with the quantitative level of D-dimer after surgery.