D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two cross-linked D fragments of the fibrin protein. Recurrent fetal loss (RPL) is one of the most common causes of sterility. Several studies identified thrombophilia as the principal cause of recurrent pregnancy loss. During pregnancy, elevated markers of coagulation and fibrinolytic system activation, such as DDimer, indicate increased thrombin activity and increased fibrinolysis following fibrin formation. Testing for D-Dimer during pregnancy could therefore be useful for the diagnosis and prediction of a venous thromboembolic event (VTE) or pregnancyrelated complications, and for monitoring antithrombotic treatment. This approach, however, is hampered by the fact that even an uncomplicated pregnancy in healthy women is accompanied by a substantial increase of D-Dimer. Miscarriage is the unintended loss of pregnancy before the period of viability. The loss of a wanted pregnancy is always distressing to the mother irrespective of its timing and this is true in recurrent abortion. The present study was aimed to assess D- dimer in Sudanese Women with Recurrent Miscarriage .This cross sectional study was conducted in Omdurman Maternity Hospital , Omdurman Khartoum state during September and October 2015, A total of (50 ) pregnant ladies with at least three miscarriage were in enrolled in this study. 2.5 ml of veinous blood were collected from each lady in trisodium citrate anticoagulant container, platelet poor plasma was mixed on the roller mixer machine and centrifuged for 15 minutes at 1500 g. The plasma was collected at the end of centrifugation and used for the D-dimer assay. They were assessed by using Fluorescence Immunoassay that the measured the D- Dimer concentration in plasma , Clinical data were collected from patient medical records. The Sudanese women with recurrent miscarriage were aged between 52 and 52 years and The mean of D-Dimer for the Sudanese women was 2785.2020 ± 2910.7098.The study revealed a clear relationship between D- dimer and recurrent abortion