The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity predisposes individuals to 2 pivotal components of metabolic syndrome: obesity and insulin resistance. Therefore, the large need is to lower down the increasing obesity across the world. To evaluate the therapeutic effect of aqueous extract of Vrikshamala (Garcinia indica) in different doses forms in High fat diet & dexamethasone induced metabolic syndrome in animal model. Statistically significant changes were observed in Serum. triglycerides, HDL and FBS levels and weight. Aqueous extract of Vrikshamala in high dose was found more effective in treating dyslipidemia and hyperglycemia which are important component of metabolic syndrome