Anemia is a common nutritional deficiency syndrome. Lead and cadmium are major hazard element to humans in industrialized countries. Zinc and copper are necessary and play vital roles in different physiologic and pathologic conditions. Cu, Fe, Zn are trace elements of our body these metals lack usually causes of hypochromic microcytic anemia. iron deficiency are not only factor of growing hypo chromic microcytic Anemia but also increases the absorption of other elements such as lead (pb)and cadmium (cd) both are heavy metals.