Monthly concentration of Lead were determined from the muscles of fish Liza parsia from three sites of Ashtamudi lake during December 2010 to November 2011.The results were expressed as µg/gm dry weight. The present study showed that the lead was found to be accumulated in the muscle of Liza parsia in all the three sites and it was found that it in the muscle it was within the permissible limit, but near to the limit envisaged a detailed investigation