ISSN
2277 - 3282
e ISSN
2277 - 3290
Publisher
Journal of Science
Professor, Department of ENT, Mallareddy Women’s Medical College, EX-Professor, Department of ENT, Osmania Medical College, Hyderabad, Telangana, India.
Assistant Professor, Department of ENT, Mallareddy Institute of Medical Sciences, Hyderabad, Telangana, India.
We undertook this study to evaluate the possible etiological factors responsible, the epidemiological pattern, role of adjuvant vitamins and anti-oxidants in oral leukoplakia. MATERIALS AND METHODS: A prospective study of a hundred patients attending the outpatient department ofboth the institutions presenting with oral white lesions. Those cases in which a specific cause (infective, systemic disease or specific disease entity) for the white lesions were elicited were excluded from the study of two institutions. A written informed consent was taken from all the patients participating in the study. Local ethical body committee approval was taken. RESULTS: In this study there was 63%homogenous, 18% ulcerative, 16% nodular and 3% verrucous type of lesions. Out of them 67% showed epithelial hyperplasia, 19% showed mild dysplasia, 10% were severely dysplasticand 15.5% of nodular/verrucous, 16.5% of ulcerative leukoplakia were confirmed histologically to be malignant.Clinical improvement was seen in 90% of cases who had reduced risk factors with antioxidant supplementations than 48.8% of those who don’t. CONCLUSION: Persistent leukoplakia has a potential for malignant transformation, toluidine blue is rapid, practical, inexpensive adjunct diagnostic tool. Anti-oxidant supplementshave beneficial effect in subjects with reduced risk factors.
5 , 8 , 2015
630 - 633