Associate Professor, Department of Pharmacology, Medical College Kolkata, 88 College Street, Kolkata-700073, West Bengal, India.

Assistant Professor, Department of Medicine, Medical College Kolkata, India, 88 College Street, Kolkata-700073, West Bengal, India.

Post Graduate Trainee, Department of Medicine, Medical College Kolkata, India, 88 College Street, Kolkata-700073, West Bengal, India.

Post Graduate Trainee, Department of Medicine, Medical College Kolkata, India, 88 College Street, Kolkata-700073, West Bengal, India.

Post Graduate Trainee, Department of Medicine, Medical College Kolkata, India, 88 College Street, Kolkata-700073, West Bengal, India.
Subarachnoid hemorrhage , Intravenous iron infusion ,Reversible cerebral vasoconstriction syndrome ,

The term subarachnoid hemorrhage (SAH) refers to extravasation of blood into the subarachnoid space between the pial and arachnoid membranes. The most common cause of subarachnoid hemorrhage is head trauma. However, nontraumatic (or spontaneous) hemorrhage usually occurs in the setting of a ruptured cerebral aneurysm or arteriovenous malformation (AVM). Iron-mediated oxidative damage has been implicated in the genesis of cerebral vasospasm in animal models of SAH. There are few case reports that showed association between iron deficiency anemia with ischemic stroke. Ischemic stroke in anemia is mainly due to a hypercoagulable state secondary to anemia, thrombocytosis secondary to iron deficiency anemia, and anemic hypoxia induced by iron deficiency anemia. In our case, twenty four hours after administration of intravenous iron infusion in the form of ferric carboxymaltose, nontraumatic subarachnoid hemorrhage occurred in a patient of iron deficiency anemia due to peptic ulcer disease. Taken together, these results highlight the deleterious potential of blood breakdown products and provide an insight into future intervention.

8 , 1 , 2018