Senior Lecturer, RVS Dental College and Hospital, Coimbatore, Tamilnadu, India.

Senior Assistant Professor, Tamilnadu Government Dental College, Chennai, Tamilnadu – 600003, India.

Professor and Vice Pricipal, Tamilnadu Government Dental College, Chennai 600003, India.

Reader, Srivenkateswara Dental College, Puducheery, India.

Professor, Tamil Nadu Government dental College and Hospital, Chennai- 600003, India.

Post graduate student, Tamilnadu Government Dental College, Chennai 600003, India.
Dendritic cells ,osteoclast ,Immune response ,Macrophages ,Differentiation. ,

Periodontitis is associated with an increase in osteoclasts formation and differentiation leading to bone resorption. Dendritic cells are antigen presenting cells crucial for adaptive and innate immune response. Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response. Dendritic cells are derived from haematopoietic bone marrow progenitor cells. These progenitor cells initially transform into immature dendritic cells. Osteoclast arise from hematopoietic stem cells (HSC) and pass through a series of differentiation stages resulting in non-dividing, multinucleated bone resorbing cells. During disease pathogenesis of inflammatory bone disorders and in response to a complex network of signals modulated by locally released cytokines, DC develop functional OC phenotype and activities in a RANKL-dependent manner during their interactions with T-cells, stromal cells. A direct contribution of certain DC subsets to inflammation-induced bone loss may prove to be a promising therapeutic target for controlling inflammation and the subsequent amelioration of bone pathology in periodontal disease. DCs may represent a cell type further down than monocytes in the OC differentiation pathway. DCs may express unknown transcription factors that favour OC differentiation. Based on phenotypic and functional characterization studies, it is suggested that DC can act as OC that further develop into DDOC with distinctive phenotype and behaviour under the inflammatory conditions

11 , 1 , 2021