177ELECTROCHEMICAL OXIDATION BEHAVIOUR OF NARINGENIN FLAVONOID USING GLASSY CARBON ELECTRODE MODIFIED WITH POLYANILINE BASED NANOSENSORSThe oxidation characteristics of the flavonoid naringenin was investigated at a glassy carbon electrode (GCE) modified with polyaniline based nanosensors in human plasma using cyclic voltammetry (CV). Here the determination of naringenin by differential pulse voltammetry (DPV) in phosphate buffer of pH 2.0–10.0, an irreversible and diffusion controlled reduction wave was developed. The dependence of the CV response of the developed anodic peak on the sweep rate (ν) and on depolizer concentration was typical of an electrode coupled chemical reaction mechanism (EC) in which an irreversible first order reaction is interposed between the charges. The values of the electron transfer coefficient involved in the rate determining step calculated from the linear plots of in the pH range investigated. In phosphate buffer of pH 6.0, a well defined oxidation peaks were developed and the plot of peak current height of the DPV against naringenin concentration at this peak potential was linear in the range 20µM to 100µM with lower limits of detection (LOD) and quantification (LOQ) of 6.25×10−9 and 8.15×10−7 mol L−1, respectively. A relative standard deviation of 1.83% (n=5) was obtained for 1.5×10-6 mol L−1 of the naringenin. These DPV procedures were successfully used for analysis of naringenin in human plasma. The method was successfully applied for the determination naringenin in human plasma.sreedharny.chem@gmail.comReview512015Naringenin,Human Plasma,Polyaniline,Differential Pulse Voltammetry,Glassy Carbon ElectrodeDhananjayulu M,Sivaprasad M, Sreedhar NYElectroanalytical Lab, Department of Chemistry, Sri Venkateswara University Tirupati-517502, Andhra Pradesh, India,Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University Tirupati-517502, Andhra Pradesh, India,Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University Tirupati-517502, Andhra Pradesh, India