215ASSOCIATION OF VITAMIN-D RECEPTOR (VDR) GENE START CODON FOKI POLYMORPHISM WITH ACUTE LYMPHOBLASTIC LEUKAEMIAThe aim of this was to investigate the association between VDR start codon FokI polymorphism and acute lymphoblastic leukaemia. A total of 72 subjects were enrolled in this study, 35 with acute lymphoblastic leukaemia , and 37 healthy individuals as a control group. Genomic DNA was extracted from patients’ blood samples by salting out method, and analyzed for detection of VDR start codon FokI polymorphism using PCR-RFLP. The results showed that, The genotype F/F was the most frequent (60%) in patients with ALL, followed by the genotype F/f(37.1%) and f/f (2.9%) consequently. Also in healthy controls the F/F genotype was the most frequent (86.5%), followed by the genotype F/f (13.5%), while the genotype f/f was absent. There was a significant association between ALL and the genotypes F/F (OR: 0.234, CI:0.073-0.748, P.value:0.014) and F/f (OR: 3.78, CI :1.179 -12.131, P.value:0.025) . In conclusion, VDR start codon F/F and F/f genotypes might confer increased risk for the development.eman.mohammadin@gmail.comResearch542015Vitamin D receptor, Start codon polymorphism,Acute lymphoblastic leukemiaEman Mohammadin Ali,Elshazali Widaa Ali,Ebtihal Ahmed Babekir,Mohanad Altayeb Mohamed AhmedDepartment of Haematology, Faculty of medical laboratory sciences, Al- Neelain University, Khartoum, Sudan.,Department of Haematology, Faculty of medical laboratory sciences, Al- Neelain University, Khartoum, Sudan.,Department of Haematology, Faculty of medical laboratory sciences, Al- Neelain University, Khartoum, Sudan.,Department of Haematology, Faculty of medical laboratory sciences, Al- Neelain University, Khartoum, Sudan.