212EFFECT OF RENAL INSUFFICIENCY ON PANCREATIC ENZYME ACTIVITIES IN SERUMThe incidence of Pancreatitis is higher in patients with renal failure than in general population13 and the non-specific increases in enzyme levels, make it difficult to diagnose this complication. Further the extent and frequency of the increase in pancreatic enzymes is under debate. The present study was undertaken to evaluate the frequency of elevated pancreatic enzymes in renal insufficiency and to identify if any relationship is there between magnitude of renal insufficiency and the increase in levels. We analyzed sera of 96 patients with varying degrees of renal insufficiency, including 30 patients with acute renal failure and 66 patients with chronic renal failure. The mean age of the patients was 42±12 years. All the patients had renal insufficiency without any clinical and morphological evidence of pancreatic disease. We estimated the blood urea, serum creatinine, amylase and lipase in the sera and calculated the correlation of co-efficient of blood urea and serum creatinine with the pancreatic enzymes. We conclude that in a setting of renal failure, amylase levels more than 10 times the URL indicate pancreatitis and lipase does not have any diagnostic value in these patients. Our data further shows that creatinine correlates better with hyperamylasemia and hyperlipasemia than urea.dr_usha_rani@yahoo.comResearch542015Creatinine,Urea,Renal insufficiency,Pancreatic enzymes,Amylase,LipaseS. Usha Rani,J. Rama Rao,K. Ambika DeviAssistant Professor,Department of Biochemistry, Mallareddy Medical College for Women, Hyderabad, Telangana, India.,Professor and HOD, Department of Biochemistry, Mallareddy Medical College for Women, Hyderabad, Telangana, India., Professor and HOD, Department of Biochemistry, Ashram Medical College, Vijayawada, Andhra Pradesh, India.