247EFFECT OF DROUGHT STRESS ON GRAIN YIELD AND P, K, CA AND MG UPTAKE OF WHEAT CULTIVARSPlants are exposed to a multitude of natural biotic and abiotic stresses. Drought is a major abiotic stress that severely affects food production worldwide Plant nutrient uptake from the soil is dependent on soil moisture, fertilizers applied, soil chemicals, and some other environmental factors. The objective of this study was to gain a better understanding of how water deficit affects grain and macronutrients yield of bread wheat cultivars. Two field experiments were conducted at the Agriculture Research Station of Saatlou in West Azarbayjan during 2010-11 and 2011-12 to examine the effects of water supply (normal irrigation and post anthesis drought stress condition) on macronutrients uptakes and grain yield in five winter wheat cultivars (Zarrin, Peshgam, Orum, Zareh and Mihan). Irrigation and cultivars showed significant differences in grain yield, and macronutrients uptakes. Grain yield and grain macronutrients uptakes (P, K, Ca and Mg) in all cultivars decreased with decreasing water availability. These results suggest that wheat cultivars respond differentially to water deficit and macronutrients. The highest grain yield per unit area under well-irrigation and water deficit was obtained for Zareh and Mihan cultivars, respectively. The highest grain P and K uptake under well-irrigation was observed Zarrin and Orum cultivars, respectively. Also in this study Zareh cultivar has the most Ca and Mg uptake under well-irrigation, but under water deficit condition Mihan has the highest grain P, K, and Mg uptake.sr.ab55@yahoo.comResearch562015Grain yield,nutrient uptake, water deficit,wheat cultivarsMohammad Rezaei,Somayyeh RazzaghiAgriculture Research Center of West Azerbaijan, Urmia, Iran,University of Çukurova, Adana/ Turkey.