257ASSESS THE KNOWLEDGE AND COMPLIANCE ON ANTICOAGULATION THERAPY AMONG PATIENT SUBJECTED TO HEART VALVE REPLACEMENT AT SRI RAMACHANDRA MEDICAL CENTRE, PORUR, CHENNAIA descriptive study design was selected for the study population of the study includes all patients who underwent heart valve replacement and on anticoagulation therapy got admitted in Sri Ramachandra Hospital by using the tool oral anti coagulation knowledge test and warfarin compliance assessment scale. The anti-coagulation knowledge test shows a mean of 11.78 with a standard deviation of 1.96 which shows the moderate level of knowledge on oral anticoagulation therapy. Whereas the warfarin compliance assessment scale shows a mean of 1.63 with a standard deviation of 0.901 which shows the inadequate level of complains level on oral anti coagulation therapy among patients subjected to heart valve replacement. There is a significant association of age, education, occupation, place of residence and monthly income, co morbid illness, duration of warfarin therapy with knowledge on oral anti coagulation at the level of p<0.05. There is a significant association of place of residence with warfarin compliance for oral anticoagulation therapy at the level of p<0.05. Assessment of knowledge and compliance on oral anticoagulation therapy during preoperative period is a safe and effective in preventing postoperative suboptimal outcomes. It can be considered as routine care during preoperative period. roshanmathaikurian@gmail.comResearch572015Anti coagulation therapy,Warfarin,Heart valve replacementRoshan mathai kurian,A Porkodi,P Akila Student M.Sc(N) ,College of Nursing, Sri Ramachandra University, Chennai, Tamil Nadu, India.,M.Sc(N), Ph.D,College of Nursing, Sri Ramachandra University, Chennai, Tamil Nadu, India.,Lecturer, Faculty of Nursing, College of Nursing, Sri Ramachandra University, Chennai, Tamil Nadu, India.