263MTHFR – A CANDIDATE GENE MARKER / SIGNATURE FOR CERVICAL CANCERCervical cancer is one of the most common cancers in women worldwide. Most cervical cancer is caused by a virus called human papillomavirus, or HPV. In recent years the incidence of endometrial and cervical cancers is on the increase and several factors have been attributed for the cause of above cancers. In the present study, a total of uterine-cervical cases (10) and controls (10) attending Dr. Rai Memorial Specialty Hospital Chennai India, taken for study. All women gave written consent for the molecular analysis of their blood samples and the Institutional Ethical Committee (IEC) approved the study. About 220 nucleotide base sequences of MTHFR gene in chromosome 1 was analysed randomly from blood samples of 11 uterine – cervical cancer patients. Out of 11 subjects 4 individuals showed heterozygous (base change) and 7 individuals showed homozygous condition. Methylene tetrahydro folate reductase encoded by the MTHFR gene catalyses the reduction of 5,10methylenetetrahydrofolatereductase to 5- methylene tetrahydro folate reductase. However it is premature to conclude the above as the MTHFR gene contains about 19322 base pairs enclosed within 11769246-11788568 on chromosome 1 (1p 36.3). It may not also be unexpected, that similar changes throughout the base sequences elsewhere happened to add to the complexicity of the cell profile changes.krmbiomed@gmail.comResearch572015MTHFR-gene,Uterine-cervical malignancy,HPV-papilloma virusK. Ramalingam,T. RajeswariDepartment of Marine Biotechnology & Centre for Marine Bioprospecting, Academy of Maritime Education and Training (AMET) University, Chennai -112, Tamil Nadu, India,PG & Research Department of Zoology and Biotechnology, Govt Arts College Nandanam, Chennai -35, Tamil Nadu, India.