305EVALUATION OF IRON STATUS AMONG SUDANESE PATIENTS WITH SICKLE CELL DISEASE RECEIVING CHRONIC RED BLOOD CELL TRANSFUSIONSickle cell disease (SCD) is type of haemoglobinopaty and its produced by single base pair change at the 6th codon of the β gene followed by replacement of anamino acid Glutamine by valine .Multiple transfusion therapy has being used more frequently to prevent and treat the complications of sickle cell disease. Iron profiles are considered to be of the most important tools in the measurement of the iron balance in steady - state sickle cell disease. Increased Gastrointestinal absorption of iron has been reported in sickle cell disease because of the associated chronic hemolysis, and it is also though that repeated red cell transfusion caused excessive iron level. This study was aimed to evaluate the body iron status in Sudanese patients with sickle cell disease receiving chronic red blood cell transfusion. A total of 50 patients diagnosed with Sickle cell disease attended to Mohammed Elameen Hamid Hospital for children Khartoum, Sudan. Blood samples were collected from each patient, and iron profile was measured using automated chemistry analyzer Mindary (BS 200). Hematological parameters were measured using automated hematology analyzer. Patients’ data was collected using structured interview, questionnaire and from patients’ medical files, and analyzed using statistical package for social sciences (SPSS) version 19. A total of 50 patients diagnosed with Sickle cell disease attended to the Mohammed Elameen Hamid Hospital for children of Khartoum state , Sudan ,24 (48%) of them were males and 26 (52%) were females; their ages ranged from 3-15 years (Mean± SD: 7.5 ±3.3). The result showed that statistically positive significant association between serum iron and number of blood bags ( P. value : 0.044), and insignificant association with TIBC ( P. value :0.80), serum ferritin( P. value :0.166) insignificant association with Hemoglobin (P. value :0.726) , Hematocrit (P. value: 0.776), MCV(P. value :0.519), MCH(P. value :0.240), MCHC(P. value :0.208). Serum iron, serum ferritin are significantly decreased and serum total iron binding capacity are significantly increased.ibrahimkh82@gmail.comResearch592015Sickle cell disease, Multiple transfusion,IronMohammed Elbashir Ibrahim Elkhalifa,Ibrahim Khider IbrahimDepartment of Haematology, Faculty of Medical Laboratory Sciences, Al neelain University, Sudan.,Department of Haematology, Faculty of Medical Laboratory Sciences, Al neelain University, Sudan.