306GLYCATED HEMOGLOBINS IN DIABETES MELLITUS -STUDY OF THEIR RELATION WITH BLOOD GLUCOSE CONCENTRATIONS, AGE OF THE PATIENT, DURATION OF DISEASE, ASSOCIATED COMPLICATIONS AND ADEQUACY OF THE TREATMENTWe compared the levels of Glycated hemoglobin and blood glucose in 52 unselected Diabetics and 30 controls. We also performed serial analyses of the parameters in 9diabetics for 4 weeks the blood sugar and the glycated hemoglobin values are significantly higher in diabetics compared to controls. There was no significant correlation between glycated hemoglobins and fasting blood glucose concentrations in controls. There was significant correlation between glycated hemoglobins and fasting blood glucose, 1hour and 2 hour blood glucose concentrations after glucose load in diabetics. The mean glycated hemoglobin levels did not correlate with age, duration of diabetes or associated chronic complications. The glycated hemoglobin values are significantly lower in diabetics whose blood glucose values are less than 130 mg/dL. (under control/ adequate treatment) compared to those whose blood glucose values are above 130 mg/dL (not under control/inadequate treatment). In patients who were followed up the values fluctuated less for glycated hemoglobin than for blood glucose. However the trends of alterations in glycated hemoglobin values paralleled the alterations in blood glucose levels. Conclusions: Glycated hemoglobins are significantly increased in diabetes mellitus correlating with increases in blood glucose. The increase in glycated hemoglobins in diabetes is not related to the age of the patient, duration of diabetes and associated complications but only to blood glucose concentrations. Glycated hemoglobin values are significantly lower in diabetics whose blood glucose values are under control with treatment. Glycated hemoglobins are better diagnostic markers and better indicators of glycemic status.janyavularamarao@gmail.comResearch592015 Glycated hemoglobin,Blood glucoseJ. Rama Rao,R. Babu Rao Professor and Head, Department of Biochemistry, Mallareddy Medical college for women, Hyderabad, Telangana, India.,Assistant Professor of Biochemistry, Osmania medical college, Hyderabad, Telangana, India.