320ROLE OF VITAMIN D STATUS IN DIABETES MELLITUS PATIENTS; VARIATION WITH AGE, SEX, SEASON AND ETHNICITY IN INDIAN POPULATIONVit-D deficiency in the general population is considerable and varies by ethnic background, sunlight exposure, and the presence of risk factors such as age, obesity, type 2 diabetes mellitus (T2DM), and other co morbidities. Its deficiency has high prevalence in both developed and developing world, has been implicated in the development of diabetes and the metabolic syndrome and it has also been shown to play a role in glycaemic control in diabetic patients. We analyzed retrospectively data from 275 Indian patients with T2DM whose serum 25(OH)D level was measured in Asian Institute of Gastroenterology hospital Hyderabad, Non diabetic healthy subjects who visited the hospital for health screening were in as the control group (Non-DM,n=85). Compared with control subjects, patients with T2DM had a lower serum 25(OH)D level (14.4±0.5 vs. 10.9±0.4 ng/ml, p<0.01). Hypovitaminosis D was common, with 76.4% (210) of patients affected with deficiency, and 12.7% (35) had insufficiency, whereas rest 10.9 %( 30) had sufficiency. In a multivariate logistic regression analysis, high levels of HbA1C, TG, and LDL-C were independently associated with Vit D deficiency in T2DM patients. A positive correlation (r = 0.155) was observed between age and vitamin D status. Statistical significance (p = 0.015) between season and vitamin D status was observed. A statistical significance (p = 0.0001) between male and female with vitamin D deficiency. An inverse relationship exists between Vitamin D status and FBG, HbA1C, TG, LDL-C. This present study showed Vitamin D deficiency and insufficiency among patients with type-2 DM and varies with age, sex, and season and ethnicity. Vitamin D is also related to glucose and lipid parameters.dr.deepikapavan@gmail.comResearch592015Hypovitaminosis,Vitamin D,InsufficiencyG.Deepika,N.Veeraiah,B.Govardhan,D.N.Reddy HOD And Consultant biochemist, Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India,Senior Biochemist,Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India,Junior Biochemist,Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India,Director and Chairman, Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.