362CORRELATION BETWEEN TUMOR MARKERS (HER2/NEU, ER, PR) AND HISTOLOGICAL GRADE AMONG SUDANESE FEMALE BREAST CANCER PATIENTSA total of 88 women were selected retrospectively from this group the tissue samples of breast cancer had been analyzed using immunohistochemical techniques to understand the tumor markers (HER2/neu, ER, and PR) with histological grade. Objective to compare the expression of tumor markers (HER2/neu, ER, and PR) with tumor histological grade. The histological grade 0 with HER2/neu+ve, ER +ve, and PR +ve are (75%), whereas among HER2/neu+ve, ER – ve, and PR – ve are (25%). The histological grade I with HER2/neu+ve, ER +ve and PR +ve are (66.7%), whereas among HER2/neu+ve, ER +ve, and PR – ve are (16.7%). While, HER2/neu+ve, ER – ve, and PR – ve are (16.7%), whereas among HER2/neu – ve, ER +ve, and PR +ve are (100%).Histological grade II with HER2/neu+ve, ER +ve, and PR +ve are (66.7%), whereas among HER2/neu+ve, ER – ve, and PR – ve are (33.3%). While, HER2/neu– ve, ER – ve, and PR +ve are (100%). The histological grade III with HER2/neu+ve, ER +ve, and PR +ve are (34.6%), whereas among HER2/neu+ve, ER +ve, and PR – ve are (7.7%). While, HER2/neu+ve, ER – ve, and PR +ve are (15.4%).The histological grade with HER2/neu+ve, ER – ve, and PR – ve are (42.3%), whereas among HER2/neu – ve, ER +ve, and PR – ve are (4%). While, HER2/neu– ve, ER +ve , and PR +ve are (4%), whereas among HER2/neu – ve, ER – ve , and PR +ve are (16%) whereas among HER2/neu – ve, ER – ve , and PR – ve are (76%). In this study population, the HER-2/neu expression and hormone receptors (ER, and PR) its relation with histological grade determined. Riyadh.36@hotmail.comResearch5112015HER2/neu,Tumor markers,Hormones receptor,Breast cancer,Histological gradeRiyadh Hamed,Yasir ElsiddigDepartment of Medical Laboratory Sciences, Buraydah Private College, KSA.,Department of Medical Laboratory Sciences, AL-GAD International College for Medical Sciences, KSA.