389IMMUNOLOGICAL STUDY OF CYTOKINE AND IMMUNOGLOBULIN A IN PATIENTS WITH DIABETES 4 MELLITUS, IRAQDiabetes Mellitus type 2 is a heterogeneous group of disorders characterized by tissue-wide insulin resistance and varies widely. Type 2 diabetes is by far the most common, affecting 90 to 95% of the diabetes population. Methods, in this study included a 50 Healthy controls , and total of (100) diabetic type(2) patients as diagnosed by Diabetolegist with an age range (25-65 years) who attended to hospitals in Babylon (AL Qasem and Marjan), during the period from January 2015 until June 2015. Result, From the results it was shown of Immunological parameters (IgA, IL4, and IL6) for DM patients were study. In this study the levels of IgA, IL4, and IL6 for DM patients were decreased. In light of the results documented in this study, one can conclude the following; The levels of Immunological parameters of IgA, IL4, and IL6 for DM patients were decreased.nadakhazal@yahoo.comReview5122015Heterogeneous group, Immunological parameters, Autoimmune destructionHayam Khalis Al-Masoudi, Ali Hussin Al-Bayti,Shatha Khazal K. Hind Department of Microbiology, College of Medicine, BabylonUniversity.Babylon province, Iraq. ,Ph.D Scholar, College of Medicine, Babylon University.Babylon province, Iraq.,Department of Microbiology, College of Medicine, BabylonUniversity.Babylon province, Iraq