383CLINICAL PROFILE AND ANTIMICROBIAL SENSITIVITY PATTERN OF PATHOGENS ISOLATED FROM URINARY TRACT INFECTION (UTI) IN WESTERN NEPALUrinary tract infection (UTI) is a common clinical problem. Due to the emergence of resistant uropathogens with widespread use of antimicrobial agents, it is important to know the sensitivity pattern at the local level to support an empiric treatment. Aim of this study is to summarize clinical profile and to detect antibiotic susceptibility pattern among pathogens isolated from UTI at Lumbini Medical College and Teaching Hospital (LMCTH). The total number of culture positive UTI cases were 316 (31.32% in males and 68.67% in females) with age ranging from 1 to 80 year. The common urinary symptoms were dysuria (56.96%), frequency (55.06%) and fever (27.21%). Escherichia coli were the most common uropathogen isolated and responsible for UTI in 57.59% patients. Staphylococcus aureus was isolated in 15.5%, proteus spp. in 10.44%, Klebsiella spp. in 9.81%, Pseudomonas aeruginosa in1.89%. E. coli was highly sensitive (>90%) to tetracycline, chloramphenicol, amikacin, tobramycin and ceftriaxone. Resistance rate was higher to Ampicillin, Amoxicillin, Cloxacillin, Erythromycin, Nalidixic acid and Norfloxacin.spdhungana@rediffmail.comResearch5122015Antimicrobial Sensitivity,Urinary tract infection,UropathogensDhungana SP,Shakya R Assistant professor, Department Of Internal Medicine, Lumbini Medical College and Teaching Hospital, Palpa, Nepal.,Senior Consultant, Department of Emergency Medicine, Lumbini Medical College and Teaching Hospital, Palpa, Nepal.