459A STUDY OF DISTRIBUTION OF NEONATAL JAUNDICE DUE TO BLOOD GROUP INCOMPATIBILITYTo study distribution of neonatal jaundice due to blood group incompatibility especially focusing on blood group irregular antibodies. Settings and design: 50 cases of neonatal pathological jaundice from Feb 2010 to Jan 2012 were studied prospectively which were further evaluated to find the distribution of ABO incompatibility, Rh incompatibility, rare group antibodies & to compare them to find out importance of all the three. ABO and Rh grouping, Antibody screening by Indirect Antihuman globulin test and Antibody identification tests were carried out on mother’s blood sample. ABO and Rh grouping, Direct Anti – human globulin test, Hemoglobin, S. Bilirubin and reticulocyte count were done on neonate’s blood sample. Additional investigations were done in selected cases. Statistical analysis used: Chi square test. The distribution of ABO and Rh incompatibility was equal (18%). Group O in neonates was seen with Rh incompatibility in 12% cases. Out of 9 ABO incompatible cases 5 cases suffered from hemolytic diseases of new born (56%). 22% positivity of DCT in Rh incompatible neonates as compared to 11% in ABO incompatible neonates. 100% positivity of DCT was seen in case of irregular antibodies. One case out of 9 Rh incompatible cases showed positive IAT (11%), none of the ABO incompatible cases showed positive IAT and one case of irregular antibody showed positive IAT (100%). Blood group incompatibility is an important cause of neonatal jaundice. This highlights the importance of routine antenatal antibody screening not just limiting to Rh negative females but in all pregnant females for ABO and irregular antibodies.hemanjainy27@yahoo.comResearch622016Neonatal jaundice,Blood group incompatibility,Irregular antibodiesSinghvi Arpita,Gupta Gajendra N,NirwanRekhaDepartment of Pathology, SantokbaDurlabhji Memorial Hospital, Jaipur, Rajasthan, India.,Department of Pathology, SantokbaDurlabhji Memorial Hospital, Jaipur, Rajasthan, India.,Department of Pathology, SantokbaDurlabhji Memorial Hospital, Jaipur, Rajasthan, India.