504SYNTHESIS, CYTOTOXICAND PRO-APOPTOTIC ACTIVITY OF CERTAIN PYRAZOLOPYRIMIDINE DERIVATIVESPyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions especially cancer. The advent of their first bioactivity as adenosine antagonistic property divulged their medicinal potential. The collective anticancer results were described.noura.sayed@hu.edu.egReview672016Pyrazolopyrimidines,Anticancer,SynthesisNoura Sayed,Rabah Ahmed Taha, Mohamed Kamal Abdel Hamid, DalaA.AbouElaPharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Egypt., Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Egypt.,Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt., Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Egypt.